Molecular basis of glutamate toxicity in retinal ganglion cells
نویسندگان
چکیده
منابع مشابه
Molecular basis of glutamate toxicity in retinal ganglion cells
Loss of retinal ganglion cells (RGCs) is a hallmark of many ophthalmic diseases including glaucoma, retinal ischemia due to central artery occlusion, anterior ischemic optic neuropathy and may be significant in optic neuritis, optic nerve trauma, and AIDS. Recent research indicates that neurotoxicity is caused by excessive stimulation of receptors for excitatory amino acids (EAAs). In particula...
متن کاملChloride channel protein 2 prevents glutamate-induced apoptosis in retinal ganglion cells
Objective(s): The purpose of this study was to investigate the role of chloride channel protein 2 (ClC-2) in glutamate-induced apoptosis in the retinal ganglion cell line (RGC-5). Materials and Methods: RGC-5 cells were treated with 1 mM glutamate for 24 hr. The expression of ClC-2, Bax, and Bcl-2 was detected by western blot analysis. Cell survival and apoptosis were measured by 3-(4,5-dimeth...
متن کاملHyperbaric pressure and increased susceptibility to glutamate toxicity in retinal ganglion cells in vitro
PURPOSE To investigate the effect of hyperbaric pressure on purified retinal ganglion cells (RGCs) and the additive effect of hyperbaric pressure on glutamate-induced RGC death. METHODS An RGC primary culture from 8-day-old Wistar rats was prepared and cultured in a hyperbaric chamber. The RGC survival rate under various pressure conditions and with 5 or 25 µM of glutamate stimulation was det...
متن کاملchloride channel protein 2 prevents glutamate-induced apoptosis in retinal ganglion cells
objective(s): the purpose of this study was to investigate the role of chloride channel protein 2 (clc-2) in glutamate-induced apoptosis in the retinal ganglion cell line (rgc-5). materials and methods: rgc-5 cells were treated with 1 mm glutamate for 24 hr. the expression of clc-2, bax, and bcl-2 was detected by western blot analysis. cell survival and apoptosis were measured by 3-(4,5-dimethy...
متن کاملMolecular biology of retinal ganglion cells.
Retinal ganglion cells are the output neurons that encode and transmit information from the eye to the brain. Their diverse physiologic and anatomic properties have been intensively studied and appear to account well for a number of psychophysical phenomena such as lateral inhibition and chromatic opponency. In this paper, we summarize our current view of retinal ganglion cell properties and po...
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ژورنال
عنوان ژورنال: Vision Research
سال: 1997
ISSN: 0042-6989
DOI: 10.1016/s0042-6989(97)00047-3